Lousy/Intensive Metabolizers, CYP2D6 The development from the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around 7% in the inhabitants has reduced activity in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme technique. These people today are “inadequate metabolizers” of debrisoquine, dextromethorphan and tricy

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